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Cholesterol drugs may help......!


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#1 Deepa Pal

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Posted 15 November 2002 - 03:00 PM

WNSO's colleagues,

Cholesterol drugs may help multiple sclerosis (MS) patients !!

Cholesterol-lowering drugs usually prescribed to prevent heart disease and stroke may also help patients suffering from multiple sclerosis (MS), researchers said on last Wednesday.

When they tested a leading cholesterol drug in mice with a similar condition to MS it reversed the paralysis caused by the illness and prevented relapses.

Scientists at the University of California, San Francisco (UCSF) and Stanford University Medical Center believe that if the drug performs as well in human trials it could be a safe, easy-to-take therapy for the progressive auto-immune disease.

"We need to have clinical trials to validate efficacy," said Scott Zamvil, an assistanct professor of neurology at UCSF.

"We have shown here for the first time that statins alter the immune response in a potentially favourable manner," he added in an interview.

The scientists used a drug called atorvastatin, which is produced by drug giant Pfizer Inc under the brand name Lipitor. It belongs to a class of drugs known as statins.

MS, which afflicts about a million people worldwide, occurs when cells in the body attack and destroy the myeline sheath which protects the nerve cells in the brain and spinal cord.

The scientists, who reported the results in the science journal nature, are hoping to conduct human trials of the drug on patients with early signs of MS.

After an initial attack of MS, which causes fatigue, numbness in the limbs and balance and visual problems, many patients do not receive treatment because there is no effective therapy and drugs for more advanced MS have side effects.

"The current forms of therapy are partially effective. They are given by injection and they are associated with side effects. The statins are well tolerated and have fewer potential side effects," Zamvil said.

Laboratory studies have shown that statins, which are swallowed, inhibit molecules in the body which are active during the early stages of MS. The drugs may also stop molecules from killing nerve cells which can occur in the later stages of MS, suggesting they could be used in combination with other treatments for the illness.

Statins may also be useful in treating other auto-immune disease such as rheumatoid arthritis and type 1, or early onset, diabetes, according to the researchers.

Merck's Zocor is another leading station. Zamvil and his colleagues found that atorvastatin prevented or reversed paralysis in the mice and interrupted an inflammatory process.

Hartmut Wekerle, of the Max Planck Institute of Neurobiology in Germany, described the research as intriguing and said it raises hope of an oral treatment for MS and other diseases.

But the stressed that only clinical trials will determine whether they produce the same effects in humans.

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source: Express News.

Thank you very much for your valuable time.
regards,

Deepa S P Pal

#2 sunil

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Posted 18 November 2002 - 05:13 AM

Dear Deepa,
MS is a very serious problem indeed. Thanks for your nice information.
Sunil Kumar Joshi
WNSO - Nepal, Kathmandu

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#3 Pooja Sahni

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Posted 02 December 2002 - 01:00 PM

Yes, it is. It is really serious problem. Thanks for your information Deepa. In time. you had posted to this subject in the forum. Good job Dear.

Pooja Sahni
Multimind is lessend, nothing for tomorrow !




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